Human SESN2 Recombinant Protein (N-His) (HD911012)

Name: Human SESN2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD911012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD911012
Descripción	Recombinant Human SESN2 Protein, N-His (HD911012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P58004
Longitud de proteína	Gly66-Thr480
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EC:1.11.1.-, Hi95, Hypoxia-induced gene, SESN2, SEST2, Sestrin-2
Fondo	Sestrin-2 is a ~54 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. 1. Budanov, AV. et al. (2008) Cell 134, 451-60. PMID: 18692468 2. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 3. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 4. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 5. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 6. Kim, H. et al. (2015) Nature communications 6, 10025. PMID: 26612684 7. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034 8. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 9. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 10. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027
Nota	For research use only

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Datasheet

Human SESN2 Recombinant Protein (N-His).pdf

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