Human SESN2 Recombinant Protein (N-His) (HD911012)

Name: Human SESN2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD911012
Price: 211 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue	HD911012
Description	Recombinant Human SESN2 Protein, N-His (HD911012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P58004
Longueur de protéine	Gly66-Thr480
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:1.11.1.-, Hi95, Hypoxia-induced gene, SESN2, SEST2, Sestrin-2
Contexte	Sestrin-2 is a ~54 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. 1. Budanov, AV. et al. (2008) Cell 134, 451-60. PMID: 18692468 2. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 3. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 4. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 5. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 6. Kim, H. et al. (2015) Nature communications 6, 10025. PMID: 26612684 7. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034 8. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 9. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 10. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027
Note	For research use only

Images

Reférences

Fiche technique

Human SESN2 Recombinant Protein (N-His).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai