Human SESN2 Recombinant Protein (N-His) (HD911012)

Name: Human SESN2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD911012
Price: 211 USD
Availability: InStock

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概要

カタログ番号	HD911012
説明	Recombinant Human SESN2 Protein, N-His (HD911012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
発現システム	E. coli
アクセッション番号	P58004
タンパク質長	Gly66-Thr480
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	EC:1.11.1.-, Hi95, Hypoxia-induced gene, SESN2, SEST2, Sestrin-2
背景	Sestrin-2 is a ~54 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1. 1. Budanov, AV. et al. (2008) Cell 134, 451-60. PMID: 18692468 2. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 3. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 4. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 5. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 6. Kim, H. et al. (2015) Nature communications 6, 10025. PMID: 26612684 7. Lear, TB. et al. (2019) The Journal of biological chemistry 294, 16527-16534. PMID: 31586034 8. Wang, D. et al. (2022) Molecular cell 82, 770-784.e9. PMID: 35114100 9. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 10. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027
注意事項	For research use only

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参考文献

データシート

Human SESN2 Recombinant Protein (N-His).pdf

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Human SESN2 Recombinant Protein (N-His) (HD911012)

概要

イメージ

参考文献

データシート

SDS

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