Human SHARPIN Recombinant Protein (N-His) (HD914012)

Name: Human SHARPIN Recombinant Protein (N-His)
Brand: abinScience
SKU: HD914012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Número de catálogo	HD914012
Descripción	Recombinant Human SHARPIN Protein, N-His (HD914012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9H0F6
Longitud de proteína	Ala18-Gly126
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	SHARPIN, SIPL1, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, Sharpin, hSIPL1
Fondo	Sharpin is a ~39 kDa protein. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. 1. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173 2. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180 3. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181 4. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331
Nota	For research use only

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Datasheet

Human SHARPIN Recombinant Protein (N-His).pdf

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