Human SLC4A7 Recombinant Protein (N-His) (HA125042)

Name: Human SLC4A7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA125042
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HA125042
Description	Recombinant Human SLC4A7 Protein, N-His (HA125042) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9Y6M7
Longueur de protéine	Gly747-His817&Ala 1114-Leu1214
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	22.19 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	BT, Bicarbonate transporter, Electroneutral Na/HCO(3) cotransporter, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4A6, SLC4A7, Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b, Sodium bicarbonate cotransporter 3, Solute carrier family 4 member 7
Contexte	Sodium bicarbonate cotransporter 3 is a ~136 kDa protein. Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. 1. Pushkin, A. et al. (1999) The Journal of biological chemistry 274, 16569-75. PMID: 10347222 2. Park, M. et al. (2002) The Journal of biological chemistry 277, 50503-9. PMID: 12403779 3. Loiselle, FB. et al. (2003) Molecular membrane biology 20, 307-17. PMID: 14578046 4. Loiselle, FB. et al. (2004) American journal of physiology. Cell physiology 286, C1423-33. PMID: 14736710 5. Sedlyarov, V. et al. (2018) Cell host & microbe 23, 766-774.e5. PMID: 29779931 6. Ali, ES. et al. (2022) Molecular cell 82, 3284-3298.e7. PMID: 35772404
Note	For research use only