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| カタログ番号 | HC904012 |
|---|---|
| 説明 |
Recombinant Human SLC9A1 Protein, N-His-KSI (HC904012) expressed in E. coli, spanning Val2-His98. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P19634 |
| タンパク質長 | Val2-His98 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 26.18 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | APNH, APNH1, NHE-1, NHE1, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, SLC9A1, Sodium/hydrogen exchanger 1, Solute carrier family 9 member 1 |
| 背景 | Sodium/hydrogen exchanger 1 is a ~90 kDa protein. Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs. 1. Pang, T. et al. (2001) The Journal of biological chemistry 276, 17367-72. PMID: 11350981 2. Murtazina, R. et al. (2001) European journal of biochemistry 268, 4674-85. PMID: 11532004 3. Slepkov, ER. et al. (2004) The Biochemical journal 379, 31-8. PMID: 14680478 4. Pang, T. et al. (2004) Biochemistry 43, 3628-36. PMID: 15035633 5. Slepkov, ER. et al. (2005) The Journal of biological chemistry 280, 17863-72. PMID: 15677483 6. Hisamitsu, T. et al. (2006) Biochemistry 45, 13346-55. PMID: 17073455 7. Pedersen, SF. et al. (2007) The Journal of biological chemistry 282, 19716-27. PMID: 17493937 8. Abu Jawdeh, BG. et al. (2011) The Journal of biological chemistry 286, 42435-42445. PMID: 22020933 9. Webb, BA. et al. (2016) The Journal of biological chemistry 291, 24096-24104. PMID: 27650500 10. Li, X. et al. (2020) Molecular and cellular biochemistry 468, 13-20. PMID: 32130622 |
| 注意事項 | For research use only |
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