ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды
Homo sapiens (Human)
Характер
Recombinant
Уровень эндотоксинов
Please contact with the lab for this information.
Чистота
>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса
26.18 kDa
Форма
Lyophilized
Буфер хранения
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
APNH, APNH1, NHE-1, NHE1, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, SLC9A1, Sodium/hydrogen exchanger 1, Solute carrier family 9 member 1
Фон
Sodium/hydrogen exchanger 1 is a ~90 kDa protein. Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.
1. Pang, T. et al. (2001) The Journal of biological chemistry 276, 17367-72. PMID: 11350981
2. Murtazina, R. et al. (2001) European journal of biochemistry 268, 4674-85. PMID: 11532004
3. Slepkov, ER. et al. (2004) The Biochemical journal 379, 31-8. PMID: 14680478
4. Pang, T. et al. (2004) Biochemistry 43, 3628-36. PMID: 15035633
5. Slepkov, ER. et al. (2005) The Journal of biological chemistry 280, 17863-72. PMID: 15677483
6. Hisamitsu, T. et al. (2006) Biochemistry 45, 13346-55. PMID: 17073455
7. Pedersen, SF. et al. (2007) The Journal of biological chemistry 282, 19716-27. PMID: 17493937
8. Abu Jawdeh, BG. et al. (2011) The Journal of biological chemistry 286, 42435-42445. PMID: 22020933
9. Webb, BA. et al. (2016) The Journal of biological chemistry 291, 24096-24104. PMID: 27650500
10. Li, X. et al. (2020) Molecular and cellular biochemistry 468, 13-20. PMID: 32130622
中文
English
한국어
日本語
Español
Français
Русский
