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| カタログ番号 | HC700012 |
|---|---|
| 説明 |
Recombinant Human SMARCA5 Protein, N-His (HC700012) expressed in E. coli, spanning Thr166-Gln634. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O60264 |
| タンパク質長 | Thr166-Gln634 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 57.10 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.6.4.-, SMARCA5, SNF2H, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, Sucrose nonfermenting protein 2 homolog, WCRF135, hSNF2H |
| 背景 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a ~121 kDa protein. ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails. Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. 1. Loyola, A. et al. (2003) Molecular and cellular biology 23, 6759-68. PMID: 12972596 2. Oppikofer, M. et al. (2017) EMBO reports 18, 1697-1706. PMID: 28801535 3. Poot, RA. et al. (2000) The EMBO journal 19, 3377-87. PMID: 10880450 4. Hakimi, MA. et al. (2002) Nature 418, 994-8. PMID: 12198550 5. Collins, N. et al. (2002) Nature genetics 32, 627-32. PMID: 12434153 6. Toiber, D. et al. (2013) Molecular cell 51, 454-68. PMID: 23911928 7. Kukimoto, I. et al. (2004) Molecular cell 13, 265-77. PMID: 14759371 |
| 注意事項 | For research use only |
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