Human SOCS7 Recombinant Protein (N-His) (HC839012)

Name: Human SOCS7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC839012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC839012
Description	Recombinant Human SOCS7 Protein, N-His (HC839012) expressed in E. coli, spanning Ser391-Thr581. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	O14512
Longueur de protéine	Ser391-Thr581
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	25.02 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	NAP-4, NAP4, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, SOCS-7, SOCS6, SOCS7, Suppressor of cytokine signaling 7
Contexte	Suppressor of cytokine signaling 7 is a ~62 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. 1. Banks, AS. et al. (2005) The Journal of clinical investigation 115, 2462-71. PMID: 16127460 2. Martens, N. et al. (2005) The Journal of biological chemistry 280, 13817-23. PMID: 15677474
Note	For research use only

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Human SOCS7 Recombinant Protein (N-His).pdf

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