Human SOCS7 Recombinant Protein (N-His) (HC839012)

Name: Human SOCS7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC839012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Обзор

Каталожный номер	HC839012
Описание	Recombinant Human SOCS7 Protein, N-His (HC839012) expressed in E. coli, spanning Ser391-Thr581. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	O14512
Длина белка	Ser391-Thr581
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	25.02 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	NAP-4, NAP4, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, SOCS-7, SOCS6, SOCS7, Suppressor of cytokine signaling 7
Фон	Suppressor of cytokine signaling 7 is a ~62 kDa protein. Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. 1. Banks, AS. et al. (2005) The Journal of clinical investigation 115, 2462-71. PMID: 16127460 2. Martens, N. et al. (2005) The Journal of biological chemistry 280, 13817-23. PMID: 15677474
Примечание	For research use only

Изображения

Ссылки

Даташит

Human SOCS7 Recombinant Protein (N-His).pdf

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Formula

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C₁ (Stock Conc.)

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Working Solution

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