Human SRGAP2 Recombinant Protein (N-His) (HF766012)

Name: Human SRGAP2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF766012
Price: 211 USD
Availability: InStock

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Número de catálogo	HF766012
Descripción	Recombinant Human SRGAP2 Protein, N-His (HF766012) expressed in E. coli, spanning Thr494-Phe679. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	O75044
Longitud de proteína	Thr494-Phe679
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	23.51 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	ARHGAP34, FNBP2, Formin-binding protein 2, KIAA0456, Rho GTPase-activating protein 34, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2, SRGAP2A, srGAP2
Fondo	SLIT-ROBO Rho GTPase-activating protein 2 is a ~120 kDa protein. Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. 1. Guo, S. et al. (2010) The Journal of biological chemistry 285, 35133-41. PMID: 20810653 2. Fossati, M. et al. (2016) Neuron 91, 356-69. PMID: 27373832 3. Sporny, M. et al. (2017) Molecular biology and evolution 34, 1463-1478. PMID: 28333212 4. Charrier, C. et al. (2012) Cell 149, 923-35. PMID: 22559944 5. Mason, FM. et al. (2011) The Journal of biological chemistry 286, 6577-86. PMID: 21148482
Nota	For research use only

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Datasheet

Human SRGAP2 Recombinant Protein (N-His).pdf

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