Human SUCNR1 Recombinant Protein (N-His-KSI) (HD131012)

Name: Human SUCNR1 Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HD131012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD131012
Description	Recombinant Human SUCNR1 Protein, N-His-KSI (HD131012) expressed in E. coli. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9BXA5
Longueur de protéine	Leu2-Gly31&Arg81-His103&Pro159-Leu185&Tyr207-Pro230&Arg252-Arg281&Arg303-Lys334
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	35.81 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	G-protein coupled receptor 91, GPR91, P2Y purinoceptor 1-like, SUCNR1, Succinate receptor 1
Contexte	Succinate receptor 1 is a ~38 kDa protein. G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated. Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis. In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells. Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function. 1. He, W. et al. (2004) Nature 429, 188-93. PMID: 15141213 2. Sundström, L. et al. (2013) FEBS letters 587, 2399-404. PMID: 23770096 3. Trauelsen, M. et al. (2021) Cell reports 35, 109246. PMID: 34133934 4. Rubic, T. et al. (2008) Nature immunology 9, 1261-9. PMID: 18820681
Note	For research use only

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Human SUCNR1 Recombinant Protein (N-His-KSI).pdf

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