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| カタログ番号 | HD131012 |
|---|---|
| 説明 |
Recombinant Human SUCNR1 Protein, N-His-KSI (HD131012) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9BXA5 |
| タンパク質長 | Leu2-Gly31&Arg81-His103&Pro159-Leu185&Tyr207-Pro230&Arg252-Arg281&Arg303-Lys334 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 35.81 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | G-protein coupled receptor 91, GPR91, P2Y purinoceptor 1-like, SUCNR1, Succinate receptor 1 |
| 背景 | Succinate receptor 1 is a ~38 kDa protein. G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated. Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis. In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells. Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function. 1. He, W. et al. (2004) Nature 429, 188-93. PMID: 15141213 2. Sundström, L. et al. (2013) FEBS letters 587, 2399-404. PMID: 23770096 3. Trauelsen, M. et al. (2021) Cell reports 35, 109246. PMID: 34133934 4. Rubic, T. et al. (2008) Nature immunology 9, 1261-9. PMID: 18820681 |
| 注意事項 | For research use only |
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