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| カタログ番号 | HD136012 |
|---|---|
| 説明 |
Recombinant Human TBC1D5 Protein, N-His (HD136012) expressed in E. coli, spanning Ser43-Ser266. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q92609 |
| タンパク質長 | Ser43-Ser266 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 28.86 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | KIAA0210, TBC1 domain family member 5, TBC1D5 |
| 背景 | TBC1 domain family member 5 is a ~89 kDa protein. May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. 1. Seaman, MN. et al. (2009) Journal of cell science 122, 2371-82. PMID: 19531583 2. Harbour, ME. et al. (2010) Journal of cell science 123, 3703-17. PMID: 20923837 3. Popovic, D. et al. (2012) Molecular and cellular biology 32, 1733-44. PMID: 22354992 4. Popovic, D. et al. (2014) EMBO reports 15, 392-401. PMID: 24603492 |
| 注意事項 | For research use only |
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