Human TET3 Recombinant Protein (N-His) (HC899012)

Name: Human TET3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC899012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC899012
Descripción	Recombinant Human TET3 Protein, N-His (HC899012) expressed in E. coli, spanning Val835-Gln1140. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	O43151
Longitud de proteína	Val835-Gln1140
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	36.61 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CXXC10, EC:1.14.11.80, KIAA0401, Methylcytosine dioxygenase TET3, TET3
Fondo	Methylcytosine dioxygenase TET3 is a ~193 kDa protein. Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. 1. Beck, DB. et al. (2020) American journal of human genetics 106, 234-245. PMID: 31928709 2. Xu, Y. et al. (2012) Cell 151, 1200-13. PMID: 23217707 3. Deplus, R. et al. (2013) The EMBO journal 32, 645-55. PMID: 23353889 4. Xu, C. et al. (2018) Structure (London, England : 1993) 26, 85-95.e3. PMID: 29276034
Nota	For research use only

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Datasheet

Human TET3 Recombinant Protein (N-His).pdf

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