

| Numéro de catalogue | HP664012 |
|---|---|
| Description |
Recombinant Human TMEFF1 Protein, N-His (HP664012). Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q8IYR6 |
| Longueur de protéine | Gly86-Glu302 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 26.09 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | C9orf2, H7365, TMEFF1, TR-1, Tomoregulin-1, Transmembrane protein with EGF-like and one follistatin-like domain |
| Contexte | Tomoregulin-1 is a ~40 kDa protein. Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. May be a tumor suppressor in brain cancers. 1. Dai, Y. et al. (2024) Nature 632, 383-389. PMID: 39048823 2. Chan, YH. et al. (2024) Nature 632, 390-400. PMID: 39048830 3. Gery, S. et al. (2003) Oncogene 22, 2723-7. PMID: 12743596 |
| Note | For research use only |

SDS-PAGE for Recombinant Human TMEFF1 Protein, N-His




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