Human TNPO1 Recombinant Protein (N-His) (HV059022)

Name: Human TNPO1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV059022
Price: 211 USD
Availability: InStock

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Número de catálogo	HV059022
Descripción	Recombinant Human TNPO1 Protein, N-His (HV059022) expressed in E. coli, spanning Cys613-Val898. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q92973
Longitud de proteína	Cys613-Val898
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	34.64 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Importin beta-2, KPNB2, Karyopherin beta-2, M9 region interaction protein, MIP, MIP1, TNPO1, TRN, Transportin-1
Fondo	Transportin-1 is a ~102 kDa protein. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Barraud, P. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E1852-61. PMID: 24753571 2. Dean, KA. et al. (2001) Journal of cell science 114, 3479-85. PMID: 11682607 3. Fritz, J. et al. (2009) Molecular and cellular biology 29, 1487-97. PMID: 19124606 4. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349
Nota	For research use only

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Datasheet

Human TNPO1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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