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| カタログ番号 | HV059022 |
|---|---|
| 説明 |
Recombinant Human TNPO1 Protein, N-His (HV059022) expressed in E. coli, spanning Cys613-Val898. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q92973 |
| タンパク質長 | Cys613-Val898 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 34.64 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Importin beta-2, KPNB2, Karyopherin beta-2, M9 region interaction protein, MIP, MIP1, TNPO1, TRN, Transportin-1 |
| 背景 | Transportin-1 is a ~102 kDa protein. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Barraud, P. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E1852-61. PMID: 24753571 2. Dean, KA. et al. (2001) Journal of cell science 114, 3479-85. PMID: 11682607 3. Fritz, J. et al. (2009) Molecular and cellular biology 29, 1487-97. PMID: 19124606 4. Yang, TJ. et al. (2022) The Journal of cell biology 221. PMID: 35446349 |
| 注意事項 | For research use only |
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