中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD968012 |
|---|---|
| 説明 |
Recombinant Human TRAF2 Protein, N-His (HD968012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q12933 |
| タンパク質長 | Ser348-Leu501 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | E3 ubiquitin-protein ligase TRAF2, EC:2.3.2.27, RING-type E3 ubiquitin transferase TRAF2, TNF receptor-associated factor 2, TRAF2, TRAP3, Tumor necrosis factor type 2 receptor-associated protein 3 |
| 背景 | TNF receptor-associated factor 2 is a ~55 kDa protein. E3 ubiquitin-protein ligase that regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Catalyzes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, IKBKE, MLST8, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. 1. Baud, V. et al. (1999) Genes & development 13, 1297-308. PMID: 10346818 2. Chadee, DN. et al. (2002) Molecular and cellular biology 22, 737-49. PMID: 11784851 3. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689 4. He, L. et al. (2004) The Journal of biological chemistry 279, 55855-65. PMID: 15383523 5. Blackwell, K. et al. (2009) Molecular and cellular biology 29, 303-14. PMID: 18981220 6. Li, S. et al. (2009) Molecular cell 33, 30-42. PMID: 19150425 7. Yin, Q. et al. (2009) Biochemistry 48, 10558-67. PMID: 19810754 8. Sondarva, G. et al. (2010) Cell research 20, 89-98. PMID: 19918265 9. Li, S. et al. (2010) Molecular and cellular biochemistry 338, 11-7. PMID: 19937093 10. Sasai, M. et al. (2010) Molecular immunology 47, 1283-91. PMID: 20047764 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
