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| カタログ番号 | HD350012 |
|---|---|
| 説明 |
Recombinant Human TRAF7 Protein, N-His (HD350012) expressed in E. coli, spanning Ile385-Cys670. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q6Q0C0 |
| タンパク質長 | Ile385-Cys670 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.95 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | E3 ubiquitin-protein ligase TRAF7, EC:2.3.2.-, EC:2.3.2.27, RFWD1, RING finger and WD repeat-containing protein 1, RING finger protein 119, RING-type E3 ubiquitin transferase TRAF7, RNF119, TNF receptor-associated factor 7, TRAF7 |
| 背景 | E3 ubiquitin-protein ligase TRAF7 is a ~74 kDa protein. E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis. Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response. 1. Xu, LG. et al. (2004) The Journal of biological chemistry 279, 17278-82. PMID: 15001576 2. Huang, JP. et al. (2023) Virologica Sinica 38, 419-428. PMID: 37086853 3. Bouwmeester, T. et al. (2004) Nature cell biology 6, 97-105. PMID: 14743216 4. Zotti, T. et al. (2011) The Journal of biological chemistry 286, 22924-33. PMID: 21518757 |
| 注意事項 | For research use only |
SDS-PAGE for Human TRAF7 Recombinant Protein (N-His)
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中国武漢市深敦寺路666号C棟、武漢、430206
