Human TRPV4 Recombinant Protein (N-His) (HC206012)

Name: Human TRPV4 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC206012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC206012
Descripción	Recombinant Human TRPV4 Protein, N-His (HC206012) expressed in E. coli, spanning Arg151-Asn361. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9HBA0
Longitud de proteína	Arg151-Asn361
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	26.31 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	OTRPC4, Osm-9-like TRP channel 4, TRP12, TRPV4, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, TrpV4, VR-OAC, VRL-2, VRL2, VROAC, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel
Fondo	Transient receptor potential cation channel subfamily V member 4 is a ~98 kDa protein. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. 1. Arniges, M. et al. (2006) The Journal of biological chemistry 281, 1580-6. PMID: 16293632 2. Köttgen, M. et al. (2008) The Journal of cell biology 182, 437-47. PMID: 18695040 3. Garcia-Elias, A. et al. (2008) The Journal of biological chemistry 283, 31284-8. PMID: 18826956 4. Fiorillo, C. et al. (2012) Neurogenetics 13, 195-203. PMID: 22526352 5. Thorneloe, KS. et al. (2012) Science translational medicine 4, 159ra148. PMID: 23136043 6. Doñate-Macián, P. et al. (2018) Nature communications 9, 2307. PMID: 29899501
Nota	For research use only

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Referencias

Datasheet

Human TRPV4 Recombinant Protein (N-His).pdf

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