Human TRPV4 Recombinant Protein (N-His) (HC206012)

Name: Human TRPV4 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC206012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC206012
Description	Recombinant Human TRPV4 Protein, N-His (HC206012) expressed in E. coli, spanning Arg151-Asn361. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9HBA0
Longueur de protéine	Arg151-Asn361
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	26.31 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	OTRPC4, Osm-9-like TRP channel 4, TRP12, TRPV4, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, TrpV4, VR-OAC, VRL-2, VRL2, VROAC, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel
Contexte	Transient receptor potential cation channel subfamily V member 4 is a ~98 kDa protein. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. 1. Arniges, M. et al. (2006) The Journal of biological chemistry 281, 1580-6. PMID: 16293632 2. Köttgen, M. et al. (2008) The Journal of cell biology 182, 437-47. PMID: 18695040 3. Garcia-Elias, A. et al. (2008) The Journal of biological chemistry 283, 31284-8. PMID: 18826956 4. Fiorillo, C. et al. (2012) Neurogenetics 13, 195-203. PMID: 22526352 5. Thorneloe, KS. et al. (2012) Science translational medicine 4, 159ra148. PMID: 23136043 6. Doñate-Macián, P. et al. (2018) Nature communications 9, 2307. PMID: 29899501
Note	For research use only

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Human TRPV4 Recombinant Protein (N-His).pdf

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