Human TTBK2 Recombinant Protein (N-His) (HC224012)

Name: Human TTBK2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC224012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC224012
Descripción	Recombinant Human TTBK2 Protein, N-His (HC224012) expressed in E. coli, spanning Ser12-Gly288. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q6IQ55
Longitud de proteína	Ser12-Gly288
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	34.19 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EC:2.7.11.1, KIAA0847, TTBK2, Tau-tubulin kinase 2
Fondo	Tau-tubulin kinase 2 is a ~137 kDa protein. Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis. Required for recruitment of CPLANE2 and INTU to the mother centriole. 1. Goetz, SC. et al. (2012) Cell 151, 847-858. PMID: 23141541 2. Huang, N. et al. (2018) Nature communications 9, 4511. PMID: 30375385
Nota	For research use only

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Datasheet

Human TTBK2 Recombinant Protein (N-His).pdf

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