Human TTBK2 Recombinant Protein (N-His) (HC224012)

Name: Human TTBK2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC224012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC224012
Description	Recombinant Human TTBK2 Protein, N-His (HC224012) expressed in E. coli, spanning Ser12-Gly288. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q6IQ55
Longueur de protéine	Ser12-Gly288
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	34.19 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:2.7.11.1, KIAA0847, TTBK2, Tau-tubulin kinase 2
Contexte	Tau-tubulin kinase 2 is a ~137 kDa protein. Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis. Required for recruitment of CPLANE2 and INTU to the mother centriole. 1. Goetz, SC. et al. (2012) Cell 151, 847-858. PMID: 23141541 2. Huang, N. et al. (2018) Nature communications 9, 4511. PMID: 30375385
Note	For research use only

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Human TTBK2 Recombinant Protein (N-His).pdf

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