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| カタログ番号 | HD030012 |
|---|---|
| 説明 |
Recombinant Human TXK Protein, N-His (HD030012) expressed in E. coli, spanning Ile85-Trp527. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P42681 |
| タンパク質長 | Ile85-Trp527 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 53.87 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:2.7.10.2, PTK4, Protein-tyrosine kinase 4, RLK, Resting lymphocyte kinase, TXK, Tyrosine-protein kinase TXK |
| 背景 | Tyrosine-protein kinase TXK is a ~61 kDa protein. Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. 1. Takeba, Y. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 2365-70. PMID: 11859127 2. Maruyama, T. et al. (2007) Clinical and experimental immunology 147, 164-75. PMID: 17177976 |
| 注意事項 | For research use only |
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