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| カタログ番号 | HC949012 |
|---|---|
| 説明 |
Recombinant Human UGT1A9 Protein, N-His (HC949012) expressed in E. coli, spanning Gly26-Ile275. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O60656 |
| タンパク質長 | Gly26-Ile275 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 31.16 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:2.4.1.17, GNT1, UDP-glucuronosyltransferase 1-9, UDP-glucuronosyltransferase 1-I, UDP-glucuronosyltransferase 1A9, UDPGT 1-9, UGT-1I, UGT1, UGT1*9, UGT1-09, UGT1.9, UGT1A9, UGT1I, lugP4 |
| 背景 | UDP-glucuronosyltransferase 1A9 is a ~59 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP). Glucuronates the phytochemical ferulic acid efficently at both the phenolic or the carboxylic acid group. 1. Gagné, JF. et al. (2002) Molecular pharmacology 62, 608-17. PMID: 12181437 2. Picard, N. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 139-46. PMID: 15470161 3. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 15472229 4. Girard, H. et al. (2007) Pharmacogenetics and genomics 17, 1077-89. PMID: 18004212 5. Joseph, TB. et al. (2007) Molecular pharmaceutics 4, 883-94. PMID: 18052087 6. Alonen, A. et al. (2008) Biochemical pharmacology 76, 763-72. PMID: 18674515 7. Tang, L. et al. (2009) Molecular pharmaceutics 6, 1466-82. PMID: 19545173 8. Little, JM. et al. (2004) Journal of lipid research 45, 1694-703. PMID: 15231852 9. Li, X. et al. (2011) Drug metabolism and pharmacokinetics 26, 341-50. PMID: 21422672 10. Milne, GL. et al. (2024) Redox biology 70, 103020. PMID: 38211441 |
| 注意事項 | For research use only |
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