Human USP38 Recombinant Protein (N-His) (HD759012)

Name: Human USP38 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD759012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD759012
Description	Recombinant Human USP38 Protein, N-His (HD759012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q8NB14
Longueur de protéine	Met1-Ser420
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Deubiquitinating enzyme 38, EC:3.4.19.12, HP43.8KD, KIAA1891, USP38, Ubiquitin carboxyl-terminal hydrolase 38, Ubiquitin thioesterase 38, Ubiquitin-specific-processing protease 38
Contexte	Ubiquitin carboxyl-terminal hydrolase 38 is a ~116 kDa protein. Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response. Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation. Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells. Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1. Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage. 1. Iphöfer, A. et al. (2012) Chembiochem : a European journal of chemical biology 13, 1416-20. PMID: 22689415 2. Liu, W. et al. (2018) Biological research 51, 53. PMID: 30497519 3. Yang, Y. et al. (2020) Cancer research 80, 719-731. PMID: 31874856 4. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669 5. Lin, M. et al. (2016) Molecular cell 64, 267-281. PMID: 27692986 6. Zhan, W. et al. (2020) Oncogenesis 9, 48. PMID: 32404892 7. Xu, Z. et al. (2021) The international journal of biochemistry & cell biology 137, 106023. PMID: 34102342
Note	For research use only

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Human USP38 Recombinant Protein (N-His).pdf

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