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| カタログ番号 | HD960012 |
|---|---|
| 説明 |
Recombinant Human USP39 Protein, N-His (HD960012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q53GS9 |
| タンパク質長 | Asp99-Ala565 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.4.19.12, SAD1 homolog, U4/U6.U5 tri-snRNP-associated 65 kDa protein, USP39, Ubiquitin carboxyl-terminal hydrolase 39 |
| 背景 | Ubiquitin carboxyl-terminal hydrolase 39 is a ~65 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. 1. Peng, Y. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 3167-3178. PMID: 33127822 2. Kim, JJ. et al. (2021) Nucleic acids research 49, 11083-11102. PMID: 34614178 3. Makarova, OV. et al. (2001) The EMBO journal 20, 2553-63. PMID: 11350945 4. Agafonov, DE. et al. (2016) Science (New York, N.Y.) 351, 1416-20. PMID: 26912367 5. van Leuken, RJ. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 2710-9. PMID: 18728397 6. Wu, J. et al. (2019) Cancer letters 449, 114-124. PMID: 30771428 7. Quan, J. et al. (2023) Journal of immunology (Baltimore, Md. : 1950) 210, 640-652. PMID: 36651806 |
| 注意事項 | For research use only |
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