

| Numéro de catalogue | HB559022 |
|---|---|
| Description |
Recombinant Human USP48 Protein, N-His (HB559022) expressed in E. coli, spanning Gln423-Val559. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q86UV5 |
| Longueur de protéine | Gln423-Val559 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 18.15 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | Deubiquitinating enzyme 48, EC:3.4.19.12, USP31, USP48, Ubiquitin carboxyl-terminal hydrolase 48, Ubiquitin thioesterase 48, Ubiquitin-specific peptidase 48, Ubiquitin-specific protease 48, Ubiquitin-specific-processing protease 48 |
| Contexte | Ubiquitin carboxyl-terminal hydrolase 48 is a ~119 kDa protein. Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. 1. Tzimas, C. et al. (2006) Cellular signalling 18, 83-92. PMID: 16214042 2. Bassani, S. et al. (2021) Human molecular genetics 30, 1785-1796. PMID: 34059922 3. Antao, AM. et al. (2021) International journal of molecular sciences 22. PMID: 34445214 4. Jantaree, P. et al. (2022) Cellular and molecular life sciences : CMLS 79, 461. PMID: 35913642 5. Sánchez-Bellver, L. et al. (2022) International journal of molecular sciences 23. PMID: 36293380 6. Ren, Y. et al. (2023) Cancer research 83, 1074-1093. PMID: 36607699 |
| Note | For research use only |
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