Human USP49 Recombinant Protein (N-His) (HD948012)

Name: Human USP49 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD948012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD948012
Descripción	Recombinant Human USP49 Protein, N-His (HD948012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q70CQ1
Longitud de proteína	Ser356-Ser688
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Deubiquitinating enzyme 49, EC:3.4.19.12, USP49, Ubiquitin carboxyl-terminal hydrolase 49, Ubiquitin thioesterase 49, Ubiquitin-specific-processing protease 49
Fondo	Ubiquitin carboxyl-terminal hydrolase 49 is a ~79 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. 1. Zhang, Z. et al. (2013) Genes & development 27, 1581-95. PMID: 23824326 2. Matsui, M. et al. (2022) Gene 833, 146599. PMID: 35598681 3. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942 4. Campos-Iglesias, D. et al. (2023) Cell death & disease 14, 60. PMID: 36702832 5. Ye, L. et al. (2019) PLoS pathogens 15, e1007680. PMID: 30943264 6. Pan, T. et al. (2019) eLife 8. PMID: 31397674
Nota	For research use only

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Datasheet

Human USP49 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

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Stock Solution

C₁ (Stock Conc.)

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Working Solution

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V₂ (Working Vol.)

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