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| カタログ番号 | HD948012 |
|---|---|
| 説明 |
Recombinant Human USP49 Protein, N-His (HD948012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q70CQ1 |
| タンパク質長 | Ser356-Ser688 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Deubiquitinating enzyme 49, EC:3.4.19.12, USP49, Ubiquitin carboxyl-terminal hydrolase 49, Ubiquitin thioesterase 49, Ubiquitin-specific-processing protease 49 |
| 背景 | Ubiquitin carboxyl-terminal hydrolase 49 is a ~79 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. 1. Zhang, Z. et al. (2013) Genes & development 27, 1581-95. PMID: 23824326 2. Matsui, M. et al. (2022) Gene 833, 146599. PMID: 35598681 3. Luo, K. et al. (2017) The EMBO journal 36, 1434-1446. PMID: 28363942 4. Campos-Iglesias, D. et al. (2023) Cell death & disease 14, 60. PMID: 36702832 5. Ye, L. et al. (2019) PLoS pathogens 15, e1007680. PMID: 30943264 6. Pan, T. et al. (2019) eLife 8. PMID: 31397674 |
| 注意事項 | For research use only |
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