Human USP51 Recombinant Protein (N-His) (HD003012)

Name: Human USP51 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD003012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD003012
Description	Recombinant Human USP51 Protein, N-His (HD003012) expressed in E. coli, spanning Asn370-Asp711. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q70EK9
Longueur de protéine	Asn370-Asp711
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	41.09 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Deubiquitinating enzyme 51, EC:3.4.19.12, USP51, Ubiquitin carboxyl-terminal hydrolase 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51
Contexte	Ubiquitin carboxyl-terminal hydrolase 51 is a ~79 kDa protein. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. 1. Wang, Z. et al. (2016) Genes & development 30, 946-59. PMID: 27083998 2. Walser, F. et al. (2020) Molecular cell 80, 423-436.e9. PMID: 33022275 3. Hang, Q. et al. (2021) Nature communications 12, 4033. PMID: 34188037 4. Zhou, Z. et al. (2017) American journal of cancer research 7, 2020-2031. PMID: 29119051
Note	For research use only

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Human USP51 Recombinant Protein (N-His).pdf

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