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| カタログ番号 | HD003012 |
|---|---|
| 説明 |
Recombinant Human USP51 Protein, N-His (HD003012) expressed in E. coli, spanning Asn370-Asp711. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q70EK9 |
| タンパク質長 | Asn370-Asp711 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 41.09 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Deubiquitinating enzyme 51, EC:3.4.19.12, USP51, Ubiquitin carboxyl-terminal hydrolase 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51 |
| 背景 | Ubiquitin carboxyl-terminal hydrolase 51 is a ~79 kDa protein. Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1. 1. Wang, Z. et al. (2016) Genes & development 30, 946-59. PMID: 27083998 2. Walser, F. et al. (2020) Molecular cell 80, 423-436.e9. PMID: 33022275 3. Hang, Q. et al. (2021) Nature communications 12, 4033. PMID: 34188037 4. Zhou, Z. et al. (2017) American journal of cancer research 7, 2020-2031. PMID: 29119051 |
| 注意事項 | For research use only |
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