Human USP53 Recombinant Protein (N-His) (HD331012)

Name: Human USP53 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD331012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HD331012
Description	Recombinant Human USP53 Protein, N-His (HD331012) expressed in E. coli, spanning Ala27-Cys380. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q70EK8
Longueur de protéine	Ala27-Cys380
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	42.73 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:3.4.19.12, KIAA1350, USP53, Ubiquitin carboxyl-terminal hydrolase 53, Ubiquitin-specific peptidase 53
Contexte	Ubiquitin carboxyl-terminal hydrolase 53 is a ~120 kDa protein. Deubiquitinase that mediates 'Lys-63'-linked deubiquitination of tight junction proteins, such as MARVELD2 and LSR, and which is involved in the survival of auditory hair cells and hearing. Specifically cleaves 'Lys-63'-linked polyubiquitin chains composed of at least 3 ubiquitin molecules, while it is not able to deubiquitinate substrates with shorter ubiquitin chains: recognizes ubiquitin chain in position S2 and catalyzes en bloc cleavage of polyubiquitin chains from substrate proteins. Probably acts by modulating the barrier properties and mechanical stability of tight junctions via deubiquitination of MARVELD2 and LSR. 1. Zhang, J. et al. (2020) Liver international : official journal of the International Association for the Study of the Liver 40, 1142-1150. PMID: 32124521 2. Wendrich, K. et al. (2025) Nature chemical biology 21, 746-757. PMID: 39587316
Note	For research use only

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SDS-PAGE

SDS-PAGE for Recombinant Human USP53 Protein, N-His

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Human USP53 Recombinant Protein (N-His).pdf

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