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Human USP54 Recombinant Protein (N-His) (HD332012)

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概要
カタログ番号HD332012
説明
Recombinant Human USP54 Protein, N-His (HD332012) expressed in E. coli, spanning Gln39-Ser358. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% purity verified by SDS-PAGE.
発現システムE. coli
アクセッション番号Q70EL1
タンパク質長Gln39-Ser358
アプリケーションELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種Homo sapiens (Human)
性質 Recombinant
エンドトキシンレベル Please contact with the lab for this information.
純度 >90% as determined by SDS-PAGE.
予測分子量 38.96 kDa
形態 Lyophilized
保存バッファー Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

再構成 Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送 In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名C10orf29, EC:3.4.19.12, USP54, Ubiquitin carboxyl-terminal hydrolase 54, Ubiquitin-specific peptidase 54
背景

Ubiquitin carboxyl-terminal hydrolase 54 is a ~187 kDa protein. Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins. Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains. Not able to deubiquitinate substrates with shorter ubiquitin chains. Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation.

1. Wendrich, K. et al. (2025) Nature chemical biology 21, 746-757. PMID: 39587316
2. Zhang, C. et al. (2023) iScience 26, 105745. PMID: 36590171
注意事項 For research use only
イメージ
参考文献
Formula
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