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| カタログ番号 | HD148012 |
|---|---|
| 説明 |
Recombinant Human VPS11 Protein, N-His (HD148012) expressed in E. coli, spanning Val11-Asp356. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9H270 |
| タンパク質長 | Val11-Asp356 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 40.68 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | RING finger protein 108, RNF108, VPS11, Vacuolar protein sorting-associated protein 11 homolog, hVPS11 |
| 背景 | Vacuolar protein sorting-associated protein 11 homolog is a ~107 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. 1. Kim, BY. et al. (2001) The Journal of biological chemistry 276, 29393-402. PMID: 11382755 2. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085 3. Jiang, P. et al. (2014) Molecular biology of the cell 25, 1327-37. PMID: 24554770 4. Perini, ED. et al. (2014) Traffic (Copenhagen, Denmark) 15, 1366-89. PMID: 25266290 5. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203 6. Chirivino, D. et al. (2011) Molecular biology of the cell 22, 375-85. PMID: 21148287 7. Kvalvaag, AS. et al. (2013) Traffic (Copenhagen, Denmark) 14, 839-52. PMID: 23593995 |
| 注意事項 | For research use only |
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