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| カタログ番号 | HC782012 |
|---|---|
| 説明 |
Recombinant Human WDR59 Protein, N-His (HC782012) expressed in E. coli, spanning Ala2-Arg315. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q6PJI9 |
| タンパク質長 | Ala2-Arg315 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 38.62 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GATOR2 complex protein WDR59, KIAA1923, WD repeat-containing protein 59, WDR59 |
| 背景 | GATOR2 complex protein WDR59 is a ~109 kDa protein. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Parmigiani, A. et al. (2014) Cell reports 9, 1281-91. PMID: 25457612 3. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 4. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 5. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 6. Zhang, Y. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2212330120. PMID: 36577058 |
| 注意事項 | For research use only |
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