Human WHR1 Recombinant Protein (N-His) (HD899012)

Name: Human WHR1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD899012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HD899012
Description	Recombinant Human WHR1 Protein, N-His (HD899012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P49842
Longueur de protéine	Asp144-Thr254
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	G11, Inactive serine/threonine-protein kinase 19, Protein G11, Protein RP1, RP1, STK19, TWH19, Tandem winged helix protein formerly known as STK19, WHR1, Winged helix repair factor 1
Contexte	Winged helix repair factor 1 is a ~28 kDa protein. DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. 1. Li, Y. et al. (2024) The Journal of cell biology 223. PMID: 38252411 2. Li, J. et al. (2024) Scientific reports 14, 14098. PMID: 38890355 3. Tan, Y. et al. (2024) Nucleic acids research 52, 12767-12783. PMID: 39353615 4. Ramadhin, AR. et al. (2024) Molecular cell 84, 4740-4757.e12. PMID: 39547223 5. Mevissen, TET. et al. (2024) Cell 187, 7091-7106.e24. PMID: 39547228 6. van den Heuvel, D. et al. (2024) Cell 187, 7107-7125.e25. PMID: 39547229
Note	For research use only

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Human WHR1 Recombinant Protein (N-His).pdf

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