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| カタログ番号 | HD899012 |
|---|---|
| 説明 |
Recombinant Human WHR1 Protein, N-His (HD899012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P49842 |
| タンパク質長 | Asp144-Thr254 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | G11, Inactive serine/threonine-protein kinase 19, Protein G11, Protein RP1, RP1, STK19, TWH19, Tandem winged helix protein formerly known as STK19, WHR1, Winged helix repair factor 1 |
| 背景 | Winged helix repair factor 1 is a ~28 kDa protein. DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. 1. Li, Y. et al. (2024) The Journal of cell biology 223. PMID: 38252411 2. Li, J. et al. (2024) Scientific reports 14, 14098. PMID: 38890355 3. Tan, Y. et al. (2024) Nucleic acids research 52, 12767-12783. PMID: 39353615 4. Ramadhin, AR. et al. (2024) Molecular cell 84, 4740-4757.e12. PMID: 39547223 5. Mevissen, TET. et al. (2024) Cell 187, 7091-7106.e24. PMID: 39547228 6. van den Heuvel, D. et al. (2024) Cell 187, 7107-7125.e25. PMID: 39547229 |
| 注意事項 | For research use only |
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