Human WIPI2 Recombinant Protein (N-His) (HD733012)

Name: Human WIPI2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD733012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор

Каталожный номер	HD733012
Описание	Recombinant Human WIPI2 Protein, N-His (HD733012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q9Y4P8
Длина белка	Met1-Arg374
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	WD repeat domain phosphoinositide-interacting protein 2, WIPI-2, WIPI2, WIPI49-like protein 2
Фон	WD repeat domain phosphoinositide-interacting protein 2 is a ~49 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane. 1. Polson, HE. et al. (2010) Autophagy 6, 506-22. PMID: 20505359 2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 3. Zhao, YG. et al. (2017) Molecular cell 67, 974-989.e6. PMID: 28890335
Примечание	For research use only

Изображения

Ссылки

Даташит

Human WIPI2 Recombinant Protein (N-His).pdf

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Formula

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C₁ (Stock Conc.)

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Working Solution

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