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| カタログ番号 | HC167012 |
|---|---|
| 説明 |
Recombinant Human XBP1 Protein, N-His-SUMO & C-Strep (HC167012) expressed in E. coli, spanning Ser68-Lys151. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P17861 |
| タンパク質長 | Ser68-Lys151 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 23.40 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | TREB-5, TREB5, Tax-responsive element-binding protein 5, X-box-binding protein 1, X-box-binding protein 1, cytoplasmic form, X-box-binding protein 1, luminal form, XBP-1, XBP1, XBP2 |
| 背景 | X-box-binding protein 1 is a ~28 kDa protein. Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. 1. Reimold, AM. et al. (2001) Nature 412, 300-7. PMID: 11460154 2. Winnay, JN. et al. (2010) Nature medicine 16, 438-45. PMID: 20348923 3. Ponath, PD. et al. (1993) The Journal of biological chemistry 268, 17074-82. PMID: 8349596 |
| 注意事項 | For research use only |
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