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| カタログ番号 | HX078022 |
|---|---|
| 説明 |
Recombinant Human YBX1 Protein, N-His-KSI (HX078022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P67809 |
| タンパク質長 | Thr57-Thr126 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CBF-A, CCAAT-binding transcription factor I subunit A, DBPB, DNA-binding protein B, EFI-A, Enhancer factor I subunit A, NSEP1, Nuclease-sensitive element-binding protein 1, Y-box transcription factor, Y-box-binding protein 1, YB-1, YB1, YBX1 |
| 背景 | Y-box-binding protein 1 is a ~35 kDa protein. DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA stability. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. 1. Chen, CY. et al. (2000) Genes & development 14, 1236-48. PMID: 10817758 2. Capowski, EE. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 5970-6. PMID: 11698476 3. Gaudreault, I. et al. (2004) Nucleic acids research 32, 316-27. PMID: 14718551 4. Chattopadhyay, R. et al. (2008) Molecular and cellular biology 28, 7066-80. PMID: 18809583 5. Chen, X. et al. (2019) Nature cell biology 21, 978-990. PMID: 31358969 6. Horwitz, EM. et al. (1994) The Journal of biological chemistry 269, 14130-9. PMID: 8188694 7. Ray, D. et al. (2009) Nature biotechnology 27, 667-70. PMID: 19561594 8. Weidensdorfer, D. et al. (2009) RNA (New York, N.Y.) 15, 104-15. PMID: 19029303 |
| 注意事項 | For research use only |
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