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| カタログ番号 | HC802012 |
|---|---|
| 説明 |
Recombinant Human YTHDF1 Protein, N-His (HC802012) expressed in E. coli, spanning His365-Gln559. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9BYJ9 |
| タンパク質長 | His365-Gln559 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 25.06 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | C20orf21, DACA-1, DF1, Dermatomyositis associated with cancer putative autoantigen 1, YTH domain-containing family protein 1, YTHDF1 |
| 背景 | YTH domain-containing family protein 1 is a ~60 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs. 1. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625 2. Xu, C. et al. (2015) The Journal of biological chemistry 290, 24902-13. PMID: 26318451 3. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408 4. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921 5. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072 6. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544 |
| 注意事項 | For research use only |
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