Mouse ACE2 Recombinant Protein (C-His) (MV157011)

Name: Mouse ACE2 Recombinant Protein (C-His)
Brand: abinScience
SKU: MV157011
Price: 298 USD
Availability: InStock

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概要

カタログ番号	MV157011
説明	Recombinant Mouse ACE2 Protein, C-His (MV157011) expressed in Mammalian Cells, spanning Gln18-Thr740. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	Q8R0I0
タンパク質長	Gln18-Thr740
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Mus musculus (Mouse)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	86.38 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ACE-related carboxypeptidase, ACE2, ACEH, Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, Angiotensin-converting enzyme-related carboxypeptidase, EC:3.4.17.-, EC:3.4.17.23, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2
背景	Angiotensin-converting enzyme 2 is a ~92 kDa protein. Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. By cleavage of angiotensin II, may be an important regulator of heart function. 1. Crackower, MA. et al. (2002) Nature 417, 822-8. PMID: 12075344 2. Donoghue, M. et al. (2003) Journal of molecular and cellular cardiology 35, 1043-53. PMID: 12967627 3. Imai, Y. et al. (2005) Nature 436, 112-6. PMID: 16001071 4. Kowalczuk, S. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 2880-7. PMID: 18424768 5. Camargo, SM. et al. (2009) Gastroenterology 136, 872-82. PMID: 19185582 6. Fairweather, SJ. et al. (2012) The Biochemical journal 446, 135-48. PMID: 22677001
注意事項	For research use only

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Mouse ACE2 Recombinant Protein (C-His).pdf

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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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Mouse ACE2 Recombinant Protein (C-His) (MV157011)

概要

イメージ

参考文献

データシート

SDS

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