ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies
Mus musculus (Mouse)
Naturaleza
Recombinant
Nivel de endotoxinas
Please contact with the lab for this information.
Pureza
>90% as determined by SDS-PAGE.
Peso molecular predicho
34.95 kDa
Forma
Lyophilized
Buffer de almacenamiento
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos
CADM1, Cell adhesion molecule 1, IGSF4, IGSF4A, IgSF4, Immunoglobulin superfamily member 4, NECL-2, NECL2, Nectin-like protein 2, SYNCAM, SgIgSF, Spermatogenic immunoglobulin superfamily, SynCAM, Synaptic cell adhesion molecule, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1
Fondo
Cell adhesion molecule 1 is a ~49 kDa protein. Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo.
1. Biederer, T. et al. (2002) Science (New York, N.Y.) 297, 1525-31. PMID: 12202822
2. Fujita, E. et al. (2003) Experimental cell research 287, 57-66. PMID: 12799182
3. Shingai, T. et al. (2003) The Journal of biological chemistry 278, 35421-7. PMID: 12826663
4. Boles, KS. et al. (2005) Blood 106, 779-86. PMID: 15811952
5. Ito, A. et al. (2004) Biochemical and biophysical research communications 319, 200-6. PMID: 15158462
6. Kitamura, Y. (2005) Novartis Foundation symposium 271, 4-11; discussion 11-4, 95-9. PMID: 16605125
7. Takeuchi, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 4220-8. PMID: 19752223
8. Cortez, VS. et al. (2014) The Journal of experimental medicine 211, 623-33. PMID: 24687959
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