ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды
Mus musculus (Mouse)
Характер
Recombinant
Уровень эндотоксинов
Please contact with the lab for this information.
Чистота
>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса
34.95 kDa
Форма
Lyophilized
Буфер хранения
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
CADM1, Cell adhesion molecule 1, IGSF4, IGSF4A, IgSF4, Immunoglobulin superfamily member 4, NECL-2, NECL2, Nectin-like protein 2, SYNCAM, SgIgSF, Spermatogenic immunoglobulin superfamily, SynCAM, Synaptic cell adhesion molecule, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1
Фон
Cell adhesion molecule 1 is a ~49 kDa protein. Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo.
1. Biederer, T. et al. (2002) Science (New York, N.Y.) 297, 1525-31. PMID: 12202822
2. Fujita, E. et al. (2003) Experimental cell research 287, 57-66. PMID: 12799182
3. Shingai, T. et al. (2003) The Journal of biological chemistry 278, 35421-7. PMID: 12826663
4. Boles, KS. et al. (2005) Blood 106, 779-86. PMID: 15811952
5. Ito, A. et al. (2004) Biochemical and biophysical research communications 319, 200-6. PMID: 15158462
6. Kitamura, Y. (2005) Novartis Foundation symposium 271, 4-11; discussion 11-4, 95-9. PMID: 16605125
7. Takeuchi, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 4220-8. PMID: 19752223
8. Cortez, VS. et al. (2014) The Journal of experimental medicine 211, 623-33. PMID: 24687959
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