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| カタログ番号 | MT064012 |
|---|---|
| 説明 |
Recombinant Mouse CD5L Protein, N-His (MT064012) expressed in E. coli, spanning Thr25-Val352. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9QWK4 |
| タンパク質長 | Thr25-Val352 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 38.59 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | API6, Apoptosis inhibitor expressed by macrophages, CD5 antigen-like, CD5L, CT-2, IgM-associated peptide, SP-alpha, hAIM |
| 背景 | CD5 antigen-like is a ~38 kDa protein. Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). 1. Sanjurjo, L. et al. (2015) Journal of leukocyte biology 98, 173-84. PMID: 26048980 2. Kurokawa, J. et al. (2010) Cell metabolism 11, 479-92. PMID: 20519120 3. Iwamura, Y. et al. (2012) Biochemical and biophysical research communications 422, 476-81. PMID: 22579686 4. Kurokawa, J. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12072-7. PMID: 21730133 5. Wang, C. et al. (2015) Cell 163, 1413-27. PMID: 26607793 6. Gaublomme, JT. et al. (2015) Cell 163, 1400-12. PMID: 26607794 10. Arai, S. et al. (2016) Nature medicine 22, 183-93. PMID: 26726878 |
| 注意事項 | For research use only |
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