Mouse IGFBP2 Recombinant Protein (C-Fc) (MB875021)

Name: Mouse IGFBP2 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MB875021
Price: 298 USD
Availability: InStock

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Numéro de catalogue	MB875021
Description	Recombinant Mouse IGFBP2 Protein, C-Fc (MB875021) expressed in Mammalian Cells, spanning Met1-Gln305. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	Mammalian cells
Numéro d'accès	P47877
Longueur de protéine	Met1-Gln305
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Mus musculus (Mouse)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	59.25 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	BP2, IBP-2, IBP2, IGF-binding protein 2, IGFBP-2, IGFBP2, Insulin-like growth factor-binding protein 2
Contexte	Insulin-like growth factor-binding protein 2 is a ~32 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. 1. DeMambro, VE. et al. (2008) Endocrinology 149, 2051-61. PMID: 18276763 2. Xi, G. et al. (2016) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 31, 1300-14. PMID: 26773517
Note	For research use only

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Mouse IGFBP2 Recombinant Protein (C-Fc).pdf

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