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| カタログ番号 | MB875011 |
|---|---|
| 説明 |
Recombinant Mouse IGFBP2 Protein, C-His (MB875011) expressed in Mammalian Cells, spanning Met1-Gln305. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | Mammalian cells |
| アクセッション番号 | P47877 |
| タンパク質長 | Met1-Gln305 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.81 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BP2, IBP-2, IBP2, IGF-binding protein 2, IGFBP-2, IGFBP2, Insulin-like growth factor-binding protein 2 |
| 背景 | Insulin-like growth factor-binding protein 2 is a ~32 kDa protein. Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. 1. DeMambro, VE. et al. (2008) Endocrinology 149, 2051-61. PMID: 18276763 2. Xi, G. et al. (2016) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 31, 1300-14. PMID: 26773517 |
| 注意事項 | For research use only |
SDS-PAGE for Mouse IGFBP2 Recombinant Protein (C-His)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
