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| カタログ番号 | MC517021 |
|---|---|
| 説明 |
Recombinant Mouse IL18/IL1F4 Protein, C-Fc (MC517021) expressed in Mammalian Cells, spanning Asn36-Ser192. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | Mammalian cells |
| アクセッション番号 | P70380 |
| タンパク質長 | Asn36-Ser192 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 46.45 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | IFN-gamma-inducing factor, IGIF, IL-1 gamma, IL-18, IL18, IL1F4, Iboctadekin, Interferon gamma-inducing factor, Interleukin-1 gamma, Interleukin-18 |
| 背景 | Interleukin-18 is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. 1. Levy, M. et al. (2015) Cell 163, 1428-43. PMID: 26638072 2. Nowarski, R. et al. (2015) Cell 163, 1444-56. PMID: 26638073 3. Hara, H. et al. (2018) Cell 175, 1651-1664.e14. PMID: 30392956 |
| 注意事項 | For research use only |
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